Cells of the immune system, like those of any other, require their own metabolism to function appropriately. Diabetes is a disease of largely metabolic aetiology, yet it is now widely considered an inflammatory condition. This inflammation arises from the aberrant activation of the immune system. The Bioenergetics Group derives its name from understanding how these two worlds interact, the metabolic disturbance in diabetes and the bioenergetic response of the body’s immune system.
Contact the bioenergetics group, and others, on:
We investigate the mechanisms that fuel immune effector function in diabetes. We widen the repertoire of actionable therapeutic targets through interrogating the bioenergetic mechanisms underlying inflammation.
*Clinical study of inflammation related biomarkers in the development and progression of type-2 diabetes and its complications
*Therapeutic target discovery in controlling aberrant innate immune responses
Fawaz Alzaid (Principal investigator)
Lucie Orliaguet (PhD candidate)
Tina Ejlalmanesh (Engineer)
Ronan Thibaut (Post-doc)
Firmin FF, … Alzaid F, … Staels B, Eeckhoute J, Lefebvre P. The RBM14/CoAA-interacting, long intergenic non-coding RNA Paral1 regulates adipogenesis and coactivates the nuclear receptor PPARγ. Sci Rep. 2017
Dalmas E, Toubal A, Alzaid F, … Langin D, Clément K, Udalova IA, Venteclef N. Irf5 deficiency in macrophages promotes beneficial adipose tissue expansion and insulin sensitivity during obesity. Nat Med. 2015.