Bioenergetics
“Energy may be likened to the bending of a cross bow; decision to the releasing of the trigger” Sun Tzu
Cells of the immune system, like those of any other, require their own metabolism to function appropriately. Diabetes is a disease of largely metabolic aetiology, yet it is now widely considered an inflammatory condition. This inflammation arises from the aberrant activation of the immune system. The Bioenergetics Group derives its name from understanding how these two worlds interact, the metabolic disturbance in diabetes and the bioenergetic response of the body’s immune system.
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Key facts
Objective
We investigate the mechanisms that fuel immune effector function in diabetes. We widen the repertoire of actionable therapeutic targets through interrogating the bioenergetic mechanisms underlying inflammation.
Current studies
*Clinical study of inflammation related biomarkers in the development and progression of type-2 diabetes and its complications
*Therapeutic target discovery in controlling aberrant innate immune responses
Human resources
Charline Potier (Technician)
Tina Ejlalmanesh (Engineer)
Lucie Orliaguet (PhD candidate)
Ronan Thibaut (Post-doc)
Fawaz Alzaid (Principal investigator)
Major publications
Das M, Alzaid F, Bayry J. Regulatory T Cells under the Mercy of Mitochondria. Cell Metab. 2019
