Bioenergetics

“Energy may be likened to the bending of a cross bow; decision to the releasing of the trigger” Sun Tzu

Picture1
Metabolic machinery of activated immune cells. Mitochondria stained in red, inflammatory protein stained in green & cell nuclei stained in blue.

Cells of the immune system, like those of any other, require their own metabolism to function appropriately. Diabetes is a disease of largely metabolic aetiology, yet it is now widely considered an inflammatory condition. This inflammation arises from the aberrant activation of the immune system. The Bioenergetics Group derives its name from understanding how these two worlds interact, the metabolic disturbance in diabetes and the bioenergetic response of the body’s immune system. 

Contact the bioenergetics group, and others, on: 

[email protected]

Key facts

Objective 
We investigate the mechanisms that fuel immune effector function in diabetes. We widen the repertoire of actionable therapeutic targets through interrogating the bioenergetic mechanisms underlying inflammation. 

Current studies
*Clinical study of inflammation related biomarkers in the development and progression of type-2 diabetes and its complications
*Therapeutic target discovery in controlling aberrant innate immune responses 

Human resources

Fawaz Alzaid (Principal investigator)
Lucie Orliaguet (PhD candidate)
Tina Ejlalmanesh (Engineer)
Ronan Thibaut (Post-doc)

Major publications

Das M, Alzaid F, Bayry J. Regulatory T Cells under the Mercy of Mitochondria. Cell Metab. 2019 

Julla JB, Ballaire R, Ejlalmanesh T, Gautier JF, Venteclef N, Alzaid F. Isolation and Analysis of Human Monocytes and Adipose Tissue Macrophages. Methods Mol Biol. 2019

Drareni K, Gautier JF, Venteclef N, Alzaid F. Transcriptional control of macrophage polarisation in type 2 diabetes. Semin Immunopathol. 2019 

Liang N, … Alzaid F, …, Staels B, Venteclef N, Treuter E, Fan R. Hepatocyte-specific loss of GPS2 in mice reduces non-alcoholic steatohepatitis via activation of PPARα. Nat Commun. 2019

Brial F, Le Lay A,… Alzaid F, … Dumas ME, Gauguier D. Systems Genetics of Hepatic Metabolome Reveals Octopamine as a Target for Non-Alcoholic Fatty Liver Disease Treatment. Sci Rep. 2019

Drareni K, … Alzaid F, Treuter E, Venteclef N. GPS2 Deficiency Triggers Maladaptive White Adipose Tissue Expansion in Obesity via HIF1A Activation. Cell Rep. 2018

Laurans L, … Alzaid F, … Mallat Z, Sokol H, Taleb S. Genetic deficiency of indoleamine 2,3-dioxygenase promotes gut microbiota-mediated metabolic health. Nat Med. 2018

de Jong AJ, … Alzaid F, … Toes REM, Ioan-Facsinay A. Functional and phenotypical analysis of IL-6-secreting CD4(+) T cells in human adipose tissue. Eur J Immunol. 2018

Firmin FF, … Alzaid F, … Staels B, Eeckhoute J, Lefebvre P. The RBM14/CoAA-interacting, long intergenic non-coding RNA Paral1 regulates adipogenesis and coactivates the nuclear receptor PPARγ. Sci Rep. 2017  

Naufahu J, Alzaid F, … Murray JF. Melanin-concentrating hormone in peripheral circulation in the human. J Endocrinol. 2017

Alzaid F, Lagadec F, … Foufelle F, Venteclef N. IRF5 governs liver macrophage activation that promotes hepatic fibrosis in mice and humans. JCI Insight. 2016

Fan R, … Alzaid F, … Gautier JF, Venteclef N, Treuter E. Loss of the co-repressor GPS2 sensitizes macrophage activation upon metabolic stress induced by obesity and type 2 diabetes. Nat Med. 2016 

Dalmas E, Toubal A, Alzaid F, … Langin D, Clément K, Udalova IA, Venteclef N. Irf5 deficiency in macrophages promotes beneficial adipose tissue expansion and insulin sensitivity during obesity. Nat Med. 2015.

Alzaid F, … Sharp PA. Regulation of glucose transporter expression in human intestinal Caco-2 cells following exposure to an anthocyanin-rich berry extract. PLoS One. 2013